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Introducing new classes of plastics, metals, cartridges, lithium-ion batteries, and concentrated nicotine solutions, however, involves significantly more environmentally intensive manufacturing processes than products that are primarily made of plant material and plastic filters, as combustible cigarettes are (Goniewicz et al

The delivery method changes some risk factors, but the core issue, nicotine exposure, remains

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By downregulating the expression of p53 in BMSCs, mitophagy could be enhanced, which effectively inhibited BMSCs apoptosis and improved the outcomes of steroid-induced ONFH treated with BMSCs transplantation [104]