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The application of multi-omics techniques on large patient cohorts has significantly advanced the current understanding of LCNS tumor biology

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These scars frequently co-occur with: Hemosideric staining (brownish discoloration from iron deposits) Wide, atrophic scars (often on shins) Easy bruising Diagnostic Significance Papyraceous scarringthin, crinkled scars that resemble tissue paperis recognized in the 2017 International Classification for Ehlers-Danlos Syndrome (EDS) as a major diagnostic criterion for Classical EDS