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Some studies have concluded that smoking tobacco can increase the chances of developing gall stones that can range from a size of a sand grain to a pebble

Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]