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Study secondary efficacy endpoints (subgroups analyses) were abstinence rates evaluated according to drug cohorts (drug used to start treatment, varenicline 2 mg/day or bupropion 300 mg/day) and therapy subgroups [monotherapy or combination therapy starting at baseline or later (varenicline 2 mg/day + bupropion 150 mg/day)] regardless of randomization group (genetic group or control group)

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For several years it remained defunct, occupied only by rusty mechanical equipment and machinery, but the massive industrial building was still a recognizable landmark in Winston-Salem