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Further information regarding the NHIS cohort design, methods, and the validity of records can be found in prior research ( The purpose of this study was to investigate the association between dynamic changes in smoking habits during a 4-year follow-up period (from 2002 to 3 to 20067) and CVD (myocardial infarction, stroke, cardiovascular death) in patients newly diagnosed with chronic diseases such as HTN, DM, or dyslipidemia