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The mixed effects model for the analysis of PK parameters (AUC and C max ) was specified as follows:where, observed [e.g., ln (AUC or C max )] overall mean effect of the i th investigational product, a fixed effect effect of the j th sequence, a fixed effect effect of the k th period, fixed effect effect of the p th subject nested within the j th sequence, assumed i

These could be signs of an underlying medical condition that requires prompt evaluation and treatment.

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For Mori, daily EC use decreased from 15.2% to 13.8% for men but increased from 10.0% to 21.2% for women, while daily use among Pacific men increased from 11.7% to 16.9% and from 6.3% to 16.6% among Pacific women