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Free hemoglobin released from lysed red cells is promptly bound by haptoglobin, producing a complex that is rapidly cleared by mononuclear phagocytes

Choi BO, Kim NK, Kim SH, Kang MS, Lee S, Ahn JY, Kim OJ, Kim S, Oh D: Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions

J Biol Chem 291:68136830 Gaillard PJ, Kerklaan BM, Aftimos P, Altintas S, Jager A, Gladdines W, Lonnqvist F, Soetekouw P, Verheul H, Awada A et al (2014) Abstract CT216: Phase I dose escalating study of 2B3-101, glutathione PEGylated liposomal doxorubicin, in patients with solid tumors and brain metastases or recurrent malignant glioma

An individualized treatment plan is developed based on the severity of fatigue, specific clinical manifestations and concurrent symptoms