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Dietary intake also plays an important role in carnitine homeostasis of HD patients since the prevalence of malnutrition ranges from 18% to 75% of these cases [54]

During the early stages of APAP-induced liver injury, stressed and damaged hepatocytes release various endogenous DAMPs, such as HMGB1, 75 nuclear DNA fragments, 76 uric acid, 77 mitochondrial DNA, 76 ATP, and heat shock protein-70, an inducible stress response protein that is translocated to the cell surface and released during cellular stress or necrotic death

Dual modifications, such as 2,4- and 2,5-sugar modifications, have been employed in the development of siRNA therapeutics to further expand the potential of ribose modifications