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In the brain, the G3PS is likely most active in polydendrocytes and oligodendrocytes due to the moderate, roughly equal expression of both GPD1 and GPD2 in these cell types, followed by astrocytes and neurons, and then by microglia due to the lower expression levels of GPD1 and GPD1L in these cell types (Supplementary Table 1

This is meaningful because insulin resistance in muscle is one of the earliest signs of metabolic dysfunction, and one of the harder things to reverse with diet alone

A recent study found that exogenous GSSG restores carbapenem susceptibility in E