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Nature 456 , 809813 (2008)

IGF-1 LR3 binds the alpha subunit of the IGF-1 receptor tyrosine kinase, inducing autophosphorylation of the beta subunit on specific tyrosine residues (Y1131, Y1135, Y1136) that create docking sites for insulin receptor substrate (IRS) proteins and Shc adaptor proteins

Epithalon decelerates ageing and suppresses development of breast adenocarcinomas in transgenic HER-2/neu mice

For example, senescent T-cells are accumulated in visceral adipose tissues in obesity 67 and produce proinflammatory cytokines, leading to chronic inflammation, metabolic disorders, and cardiovascular diseases 68,69