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doi: 10.1093/jpp/rgac069 230 WangQQiBShiSJiangWLiDJiangXet al

revealed that in liver cancer, hypoxia activates MAT2A expression through hypoxia-inducible factor-1, resulting in increased MAT II enzyme activity and reduced SAM production, which then induces genomic DNA demethylation

255 demonstrated that GO nanosheets can induce severe mitochondrial fragmentation in cancerous and healthy cells via a physical cutting mechanism, dependent on nanosheet size and concentration