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Mitochondria-dependent ferroptosis also plays a critical role in the progression of AIC (69, 70)

Sure enough, a popular sports medicine site confirms: Athletes with sickle cell trait are potentially more vulnerable to other serious conditions such as gross hematuria, splenic infarction, exertional heat stroke, severe muscle breakdown (rhabdomyolysis) and potentially even sudden death when participating in strenuous exercise under intense environmental conditions. Short of these devastating problems, which occur rarely with just the trait, more common symptoms may include muscle cramping/pain

We took the minimum number of clusters, k , where at least half of the clusters had a median Jaccard index of 0.5 or higher

These changes in the central nervous system can cause symptoms of anxiety and depression [104]an unsurprising finding, considering that brain regions like the hippocampus and prefrontal cortex, both of which are critical in MDD, are among the most affected by OS