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To test this possibility, we performed CRISPR-Cas9 based genetic screens in both Jurkat and HEK-293T cells using a metabolism focused sgRNA library 20 and searched for genes essential for cellular proliferation in the absence of SLC25A39 (Fig

Due to the non-apoptotic nature of ferroptosis, ferroptosis-based cancer treatments are expected to bypass the shortcomings of traditional therapies mediated by apoptotic pathways [225]

Statistical analysis Statistical analyses were performed using GraphPad Prism

Patients with moderate-to-severe noise-induced hearing loss resulting from prolonged occupational noise exposure have been shown to exhibit distinct patterns of audiometric changes, depending on the presence or absence of tinnitus