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The four senolytic chloroacetamides (referred to as SCLA1, SCLA2, SCLA3 and SCLA4 herein) selectively killed SK-MEL-103 cells undergoing senescence triggered by etoposide, tozasertib or palbociclib (a CDK4/6 inhibitor) (Fig

The peptide enhances growth factor expression including fibroblast growth factor (FGF) and epidermal growth factor (EGF), while simultaneously reducing pro-inflammatory cytokines like TNF- and IL-6

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These molecular impacts hamper insulin signaling by oxidative modification of insulin receptor substrates (IRS) and downstream kinases, thereby aggravating insulin resistance (IR) (25)