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[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed

Fluoxetine promotes remission in acute experimental autoimmune encephalomyelitis in rats

In general, rapid or unexplained weight shifts can signal that something is off and warrant evaluation from a clinician

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