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These oxidative entities have dual effects on nuclear factor (NF)-B signaling, either activating or inhibiting it to produce anti- or pro-oxidative responses 12

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These distinct evolutionary classes include Alpha, Beta, Dehydroascorbate reductases (DHARs), Delta, Epsilon, Mu, Omega, Pi, Phi, Sigma, Tau, Theta, and Zeta

The Multilayered Antioxidant Defense Network Corresponding to the production of ROS, organisms have developed an antioxidant system to prevent the excessive accumulation of ROS and defend against oxidative stress