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For metformin users, the MHRA recommends periodic monitoring, especially in those with symptoms suggestive of B12 deficiency

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A number of satiety signals that are released from the intestine include cholecystokinin (CCK), pancreatic polypeptide (PP), peptide-YY (PYY), oxyntomodulin, enterostatin, and glucagon -like peptide-1 (GLP-1) [5-10]

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