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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

The barrier prevents the entry of lipophilic substances that may be neurotoxic via an active transport mechanism

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Glutathione: A powerful antioxidant that helps brighten the complexion and protect the skin from environmental stressors