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Yes, excessive Brazil nut consumption can cause selenium toxicity (selenosis), resulting in hair loss, brittle nails, gastrointestinal disturbances, neurological symptoms, and in severe cases, liver and kidney damage

Sources: Raun K, et al

Department of Health and Human Services announced the reclassification of approximately 14 peptides from FDA Category 2 which had prohibited compounding since 2023 back to Category 1, restoring legal access through licensed compounding pharmacies under physician prescription

Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy