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Retatrutide for type 2 diabetes: Phase 2 trial results (36-week study, HbA1c reductions, weight loss) New England Journal of Medicine (2023) Jastreboff AM, et al

The concern stems from BPC-157s ability to promote angiogenesis, the formation of new blood vessels

Its mechanisms include: Nitric oxide modulation regulates blood flow and inflammation at injury sites Growth factor upregulation increases EGF, FGF, and VEGF expression Gut-brain axis signaling systemic effects mediated through the GI tract Dopaminergic system interaction neuroprotective properties BPC-157 is unique among healing peptides because it works systemically through the gut , even when administered locally

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