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With advancements in HRW preparation methods, such as water electrolysis (Santos et al., 2017), metal-acid reactions (Xie et al., 2020), and high-pressure dissolution, an increasing number of clinical trials have begun to adopt the consumption of hydrogen-rich water as a means of hydrogen intake for the treatment of neurological disorders

336 The CONFIRMS trial provided evidence that a daily dosage of 80 mg of febuxostat is more efficacious in lowering serum uric acid levels than a 300 mg daily dose of allopurinol

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