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[21] One was part of a crew fighting the fire, and the other had been acting as support

This suppresses transcription of pro-inflammatory genes, reducing TNF-alpha production and IL-6 secretion

Thus, copper deficiency in cardiomyocytes significantly reduces the expression of copper chaperones and the enzymatic activity of CCO, leading to a decrease in left ventricular (LV) copper content and impaired LV contractile function in dilated cardiomyopathy (111)