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Additional roles of ALDH2: In addition to breaking down alcohols, ALDHD also metabolizes:[ref] Retinol (vitamin A) Bile acids lipid peroxidation products neurotransmitter metabolites Studies link genetic variants in ALDH2 to increased risk of Alzheimers disease, possibly due to the decreased ability to break down lipid peroxidation products in the brain

While the most extensive Vitamin E studies have been performed on diabetics with higher levels of oxidative stress, researchers have found a link between supplements and increased glutathione levels

Remarkably, mutation of each residue to alanine completely abolished the uptake of glutathione, without impacting the levels of NAD+ (Fig

Dutra, F