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Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

These effects are downstream of better sleep and improved metabolic function rather than a direct neurological effect of the peptide, which makes them durable rather than temporary

Typical experimental endpoints include measures of collagen and extracellular matrix protein expression, cell migration rates, cytoskeletal organization, and transcriptional changes in genes related to tissue structure and repair, depending on the model

The total course of Accutane usually lasts about twenty weeks