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People with the following should discuss risks carefully with a medical professional: Liver disease Kidney disease Pernicious anemia Known allergies to any ingredient in the formulation Pregnancy or breastfeeding (safety not well-studied avoid unless prescribed) Because ingredients differ between providers, always verify the formulation and follow prescribed dosing to minimize risk

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Studies suggest that AOD9604 does not bind the growth hormone receptor and does not activate the JAK2/STAT5 pathway, which accounts for the absence of growth-promoting or IGF-1-elevating effects observed in animal studies

Peter Attia, a longevity physician, discusses NAD+ precursors: "While evidence is emerging, NAD+ boosting shows promise for mitochondrial health and longevity, though IV might not be optimalprecursors like NMN could be better."[33][20] On combinations, he cautions on long-term data but notes potential for metabolic disorders