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Likewise, reduced dehydroascorbic acid (an oxidized form of ascorbic acid) combined with increased threonic acid (a major breakdown product of ascorbic acid) levels in the CSF indicates a change in oxidative stress response: dehydroascorbic acid has neuroprotective effects against free radicals in the brain, while threonic acid may interfere with the metabolism of ascorbic acid [137]

& Vodnar, D.-C

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Butyrate increases the expression of TLRs which are involved in antiviral mechanisms and may also inhibit SARS-CoV-2 replication by downregulating high-mobility group box protein-1 (HMGB1) expression (Li J