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Germline EGFR T790M has since been found in multiple unrelated kindreds, predominantly comprising white individuals in the USA, Europe and Australia, more frequently in never-smoking women, and in association with multiple primary lung lesions (either nodules or invasive adenocarcinomas) 193196

Given its pivotal role in ameliorating oxidative stress/damage, GST activity has been repeatedly investigated as a biomarker for arthritis, asthma, COPD, and multiple forms of cancer, as well as an environmental marker