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doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao

Traditionally, it has been believed that estrogen and progesterone primarily drive the development and progression of uterine fibroids

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In particular, compared with granulosa cells in the control group (COGC), the expression of ferritinophagy-related genes that regulate ferroptosis was also abnormal in the EMGC group (Fig