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It has been reported that the N-terminus of DAT is essential for protein kinase C-mediated phosphorylation on serine residues [67], and the first 22 amino acids from the N-terminus of DAT eliminate phosphorylation of DAT in response to PKC activation [44]

In tau transgenic mice we saw improvements in brain structure and function by reducing senescent cell burden by 30% with an intermittent treatment strategy (35), which is consistent with preclinical studies on other models of aging and/or disease (37, 45, 46, 101-103, 108-112)

Liver PSAT1 is required for SAAR-induced improvements in systemic glucose homeostasis To assess whether hepatic serine synthesis is essential for the metabolic benefits of dietary SAAR on glucose control, we studied liver-specific PSAT1 KO mice and WT littermates fed a HF-CTRL or -SAAR diet (Fig

Tendon and ligament injuries are among the most stubborn problems in musculoskeletal medicine