Our data revealed a significant increase in the levels of IL-10 and TGF-1 across the L-GSH and L-GSH plus RIF treatment groups
Glutathione (GSH) is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain.It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides
Beside a direct anti-inflammatory effect on infiltrating immune cells and resident glial cells, cortistatin may also avoid the infiltration of macrophages and neutrophils to the inflamed nerve by decreasing the release of a chemokine, such as CCL2, that is critically involved in the progression of neuropathic pain [59]
Arterioscler Thromb Vasc Biol 28:13851391 Momiyama Y, Kawaguchi A, Kajiwara I, Ohmori R, Okada K, Saito I, Konishi M, Nakamura M, Sato S, Kokubo Y, Mannami T, Adachi H, Kario K, Iso H, Ohsuzu F, Tsushima M (2009) Prognostic value of plasma high-sensitivity C-reactive protein levels in Japanese patients with stable coronary artery disease: the Japan NCVC-Collaborative Inflammation Cohort Study
