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As the glutamate-induced swelling is sensitive to the specific K + channel blockers, namely Ba 2+ and tetraethylammonium (TEA), it is likely that delayed outwardly and inwardly rectifying K + channels are involved (Bender et al., Regulatory Volume Decrease (RVD) As uncontrolled volume changes are harmful to cells and may eventually lead to cell death, mechanisms controlling the cell volume are essential for physiological cell functioning