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Moreover, molecular, biochemical and behavioral abnormalities associated with autism phenotypes have been observed in various Wnt pathway-associated knockout mouse models ( 3.4 Gut microbiology and immune dysregulation Patients with ASD frequently exhibit comorbid GI dysfunction, a phenomenon that may be mechanistically linked to the complex interplay between the GI system and neuroendocrine/neuroimmune systems (Vuong and Hsiao, 2017