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Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination

However, previous studies have indicated that some antibodies used in ELISA kits available on the market for quantifying pro- or mBDNF may exhibit low specificity, often failing to distinguish between both isoforms 31,32

Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plantbased diet (vegan) adults. Experimental and Therapeutic Medicine 22(3) (2021): 17

Additionally, some users have experienced gastrointestinal issues such as nausea and diarrhea, which, while often temporary, can affect adherence to the medication