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According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness

The level of murine double minute 2 (MDM2) was significantly upregulated in neurons of SOD1 G93A transgenic mice

Collectively, these data suggest that albumin triggers an alternative pathogenicity pathway, independent of classical virulence mechanisms