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These results justify the reason why individuals complain that they experience excess histamine dumps, which are sporadic exacerbation of symptoms during sleep leading to itch palpitations and awakenings

Furthermore, since research indicates that bipolar disorder is a progressive illness, possibly characterized by disparate pathophysiologic substrates in different phases of illness, one can make a case for stratifying the sample based base on the stage of the illness (85, 86)

Molecular Aspects of Medicine, 30(1-2), 1-12