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MDD diagnostic status, overall depression severity and profiles The presence of DSM-IV diagnosis of MDD was assessed using the Composite Interview Diagnostic Instrument version 2.1 [35] administered by specially trained research staff

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A hint to their possible formation is to consider that the thioethers of reactive electrophiles with glutathione, cysteine and N- acetyl-cysteine can undergo in the kidney a -elimination reaction to yield a thiol compound and a reactive, electrophilic dehydro-alanine derivative

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