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The temperature was kept at 300 K in all simulations using a velocity rescaling thermostat 36 , and the pressure was kept at 1 bar (using a Berendsen barostat 37 for the equilibration steps and a ParrinelloRahman barostat 38 for the production)

Sinomenine, tripterygium glycosides and total glucosides of paeony have been clinically used for the treatment of RA

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Multiple convergent survival signals explain robust neuroprotection from neurotrophic factors and mimicking peptides